BDBM222178 Rilpivirine
SMILES Cc1cc(\C=C\C#N)cc(C)c1Nc1ccnc(Nc2ccc(cc2)C#N)n1
InChI Key InChIKey=YIBOMRUWOWDFLG-ONEGZZNKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 222178
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataEC50: 3.60nMAssay Description:Inhibition of rilpivirine-resistant HIV1 NL4-3 reverse transcriptase E138K mutant infected in human TZM-b1 cells after 2 days by bright Glo-luciferas...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of HIV1 Reverse transcriptase by primer extension-based scintillation assayMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of HIV1 reverse transcriptase p66/p51 using poly(rA)/oligo(dT)16 as template/primer measured after 40 mins by pico-green based spectrofluo...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of HIV1 reverse transcriptase p66/p51 using poly(rA)/oligo(dT)16 as template/primer measured after 40 mins by pico-green based spectrofluo...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of HIV1 Reverse transcriptase polymerase assessed as decrease in digoxigenin and biotin-dUTP incorporation into DNA using poly(A)/oligo(dT...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Murine leukemia virus reverse transcriptase RNase H using 18-nucleotide 3'-fluorescein-labeled RNA/5'-dabcyl-labeled DNA hybrid as subs...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HIV1 RT in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] incubated for 1 hr b...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of HIV1 RT K103N mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] incubat...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of HIV1 RT Y181C mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] incubat...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of HIV1 RT E138K mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] incubat...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HIV1 RT V106A/F227L mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] i...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of HIV1 RT L100I mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] incubat...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of HIV1 RT Y188L mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] incubat...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of HIV1 RT K103N/Y181C mutant in presence of reconstituted template and viral nucleotides [digoxigenin (DIG)-dUTP, biotin-dUTP and dTTP] i...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 0.680nMAssay Description:Inhibition of recombinant HIV1 reverse transcriptase p66/p51 Y181C mutant expressed in Escherichia coli BL21 (DE3) pLysS cells preincubated followed ...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataEC50: 0.200nMAssay Description:Inhibition of HIV-1 reverse transcriptase K103N mutant assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataEC50: 0.300nMAssay Description:Inhibition of HIV-1 reverse transcriptase E138K mutant assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataEC50: 1.30nMAssay Description:Inhibition of HIV-1 reverse transcriptase Y181C mutant assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataEC50: 2.30nMAssay Description:Inhibition of HIV-1 reverse transcriptase Y188L mutant assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Beijing Institute Of Pharmacology & Toxicology
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of wild-type HIV-1 reverse transcriptase by fluorescence assayMore data for this Ligand-Target Pair